Quantitative Biomechanics for Cell, Tissue & Molecular Interaction Studies
Product Overview
The CellHesion 300 by Bruker is a high-performance, automated system for single-cell force spectroscopy (SCFS) and nanomechanical characterization of living biological samples. Designed to operate under near-physiological conditions, the CellHesion 300 enables researchers to perform highly sensitive, reproducible measurements of cell-cell, cell-substrate, and tissue interactions at single-molecule resolution.
Its advanced automation, high-throughput design, and seamless integration with optical microscopy platforms make it an invaluable tool in regenerative medicine, oncology, tissue engineering, developmental biology, and immunology.
Key Features
- Automated Single-Cell Force Spectroscopy (SCFS): Quantify adhesion, tether formation, unbinding events, and more with single-molecule sensitivity.
- SmartMapping & Region-of-Interest (ROI) Selection: Flexible 2D force map design with automatic Z-position control and precise motorized stage navigation.
- High-Throughput Nanomechanics: Batch processing of large datasets with automatic parameter extraction—ideal for screening tissues and materials.
- Seamless Optical Integration: Compatible with upright, inverted, and advanced optical microscopes (e.g., fluorescence, DIC, TIRF, STED, CLSM).
- Near-Physiological Environment Control: Maintain temperature, humidity, and CO₂ levels using dedicated sample holders and accessories.
- Correlated Mechanical & Optical Imaging: Overlay biomechanical force maps on fluorescence or phase-contrast images for multiparametric analysis.
Specifications
| Category | Details |
|---|---|
| Vertical Z Travel | >19 mm (with large motorized Z-travel system) |
| Z-Scanner | 100 µm capacitive scanner (880 nm/980 nm); optional 15 µm Z-piezo |
| Precision Stage | Motorized/Manual, 20 mm × 20 mm travel range |
| Microscope Compatibility | Zeiss, Nikon, Leica, Olympus (upright and inverted) |
| Sample Types | Coverslips, Petri dishes, microscope slides, SPM discs |
| Optical Integration | Brightfield, Phase Contrast, Fluorescence, TIRF, CLSM, STED, STORM |
| Operating Modes | Contact Mode, Force Mapping, SmartMapping, Force Clamp |
| Software Capabilities | Automated alignment, batch processing, scripting, 3D rendering, FFT |
| Optional Modules | Microrheology, DirectOverlay, ExperimentPlanner, FluidFM® Add-on |
| Environmental Control | Heating, CO₂ regulation, humidity control (via accessories) |
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