High-Speed, High-Resolution AFM for Dynamic Biological Studies
Product Overview
The Dimension FastScan Bio AFM is engineered for real-time, high-resolution imaging of dynamic biological processes. With temporal resolution up to 3 frames per second, it allows researchers to observe live samples, such as biomolecules, proteins, DNA, RNA, and living cell membranes, under physiological conditions. Built upon Bruker's advanced large-sample AFM platform, the FastScan Bio integrates specialized life science features, facilitating studies of interacting molecules, membrane proteins, DNA-protein binding, inter-cellular signaling, and other dynamic biological phenomena .
Key Features
- High-Speed Scanning: Achieves up to 3 frames per second, enabling real-time observation of biological dynamics.
- Simplified Operation: User-friendly interface with Smart Engage algorithms for easy sample engagement and control.
- Real-Time Imaging: Allows immediate panning, zooming, and scanning of samples in fluid environments.
- Advanced Probe Design: Innovative cantilever shapes and coatings provide a balance of imaging speed and gentleness.
- Micro-Volume Fluid Cell: Equipped with controlled fluid exchange for maintaining sample conditions.
- Feature Tracking and Movie Creation: Tools for monitoring dynamic processes and generating time-lapse visualizations.
Specifications
| Specification | Details |
|---|---|
| Temporal Resolution | Up to 3 frames per second |
| X-Y Tip Velocity | >2 mm/s with 1% tracking error |
| Z Tip Velocity | Maximum 12 mm/s |
| Scanner Size (X, Y axis) | Typical 35 μm × 35 μm; Minimum 30 μm × 30 μm |
| Vertical Range (Z axis) | 3 μm |
| Sample Environment | Flow cell with 60 μL volume |
| Sample Heating Stage | Ambient to 120°C (Air); Ambient to 45°C (Fluid, specimen on glass slide) |
| Imaging Mode | TappingMode™ under aqueous conditions |
| Probe Compatibility | Supports FastScan-D, FastScan-B, and FastScan-C probes |
Applications
Academia & Research Institutions
- Biomolecular Studies: Real-time visualization of DNA-protein interactions, membrane protein dynamics, and cellular processes.
- Nanomaterials Research: Investigation of DNA origami structures and other nanoscale assemblies.
- Educational Tool: Facilitates hands-on learning in advanced microscopy techniques.
Electrical & Electronic Materials
- Device Fabrication: Assessment of nanoscale features in electronic components and materials.
- Quality Control: Monitoring of surface roughness and uniformity in conductive and insulating layers.
Semiconductor Industry
- Surface Characterization: Analysis of thin films, coatings, and nanostructures with high spatial resolution.
- Material Science: Examination of polymer blends, composites, and other materials at the nanoscale.
Resources
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