Redefining Tissue and Biofluid Analysis with Raman Imaging
Product Overview
The RA816 Biological Analyser is a compact, benchtop Raman imaging system designed specifically for biological and clinical research applications. It provides rapid, detailed biochemical information about tissue biopsies, tissue sections, and biofluids—without the need for dyes, labels, or extensive sample preparation.
Integrating Renishaw’s proven StreamLine and LiveTrack technologies, the RA816 enables fast, high-resolution, non-invasive chemical imaging while maintaining focus on uneven samples. Its powerful, easy-to-use software automates data acquisition, classification model building, and multivariate analysis, making it the ideal toolkit for researchers aiming to translate Raman technology into clinical practice.
Key Features
- Non-Invasive, Label-Free Analysis: Measures multiple molecular constituents in biological samples simultaneously, preserving sample integrity.
- High-Speed Data Collection: StreamLine technology enables collection of over 1500 spectra per second without damaging samples.
- Automatic Focus Tracking: LiveTrack dynamic focus tracking keeps irregular or rough samples in focus during Raman mapping.
- Macro and Micro Imaging Modes: Supports high-magnification imaging and wide-area tiled imaging up to 134 mm × 76 mm.
- Powerful Multivariate Analysis Tools: Build, test, and validate pathology and disease classification models directly within the system.
- Pre-Configured Experiment Templates: Simplify operation across a wide range of biological sample types.
- Compact and Robust Design: Small footprint (720 × 502 × 535 mm) and easily transportable between laboratories and clinics.
- Full System Self-Calibration: Integrated neon, silicon, and polystyrene standards for automated system performance validation.
Specifications
| Specification | Details |
|---|---|
| Laser Wavelength | 785 nm (integrated Renishaw high-power diode laser) |
| Spectral Range | 100–3250 cm⁻¹ (two separate scan ranges) |
| Spectral Dispersion | 2 cm⁻¹ per pixel |
| Data Collection Speed | >1500 spectra/sec |
| Minimum Pixel Size (Spatial Resolution) | 1 µm |
| Objectives | 50× long working distance objective (0.55 NA) + macro video camera |
| Field of View (Macro) | 21 mm × 16 mm |
| Field of View (Micro) | 330 µm × 250 µm |
| Max Tiled Image Size | 134 mm × 76 mm (macro), 112 mm × 81 mm (high mag) |
| Focusing | Manual or automatic (LiveTrack) |
| System Calibration | Self-calibration with neon and silicon references; automatic PQ data |
| Sample Size Capacity | Up to 110 mm × 90 mm × 25 mm (fits 96-well plate) |
| Dimensions (W × H × D) | 720 × 502 × 535 mm |
| System Mass | 54 kg (excluding computer) |
| Laser Class | Class 1 laser product (IEC60825-1 compliant) |
| Power Requirements | 100–240 VAC ± 10%, 50/60 Hz, 100 W maximum |
Applications
Biological and Clinical Research
- Identification and quantification of disease biomarkers
- Differentiation of tissue types and pathological states
- Investigation of protein secondary structures due to drug interactions or tissue injury
Pharmaceuticals and Biopharmaceuticals
- Non-destructive analysis of tissue sections for drug efficacy studies
- Polymorph and excipient identification within delivery matrices
- Characterization of therapeutic targets in biological environments
Academia and Research Institutes
- High-resolution imaging of biomolecular distributions
- Validation of pathology and disease models with spectral imaging
- Multivariate data analysis for early disease detection
Materials Science
- Surface chemistry and composition mapping in biological scaffolds and biomaterials
- Analysis of composite biomaterials and tissue engineering constructs
Diagnostics Research
- Building and validating classification models to stratify unknown tissue or fluid samples
- Potential translation into intraoperative decision support research
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